Categories: Drugs

Side effects of metformin


Discover the side effects of metformin.

Metformin is a drug that is mainly used as a treatment for diabetes, but like all drugs, the side effects of metformin are present during treatment.

Since its authorization in the United Kingdom in 1958 and in the United States in 1995, metformin has become the most widely used drug for the treatment of type 2 diabetes mellitus . It is, in fact, the first-line treatment for patients with this disease, according to the guidelines of the American Diabetes Association and the European Association for the Study of Diabetes.

Now, although it is the most common way to use this medicine, it is not the only one, since it is indicated in the treatment of polycystic ovary syndrome and also reduces the risk of suffering from cardiovascular diseases. Therefore, it will be interesting to know its uses, dosage and side effects. Its use should always be under medical prescription.

Formula : C4H11N5 _ _ _ _

Molar mass: 129.164 g/mol

Half life : 6.2 hours

Bioavailability : 50 to 60% fasting


Solubility in water: 0.285 mg/mL (20 °C)

Mol. wt.: 129.164 g/mol; 165.63 g/mol (hydrochloride)

Legal status : POM (UK) ℞-only (USA)

According to a study conducted by the National Studies of Health, metformin improves the quality of life of patients with diabetes and significantly reduces blood cholesterol and triglyceride levels.Side effects of metforminSide effects of metformin

How does Metformin work?

In two ways; first by suppressing the production of glucose in the liver, thus producing a decrease in its blood levels. And second, by increasing insulin sensitivity, by activating a protein called GLUT4 , which allows cells to absorb more glucose. 

Take action to control diabetes

Improving the reaction of insulin in the body is the main function fulfilled by Metformin, which is why it is indicated for patients suffering from type 2 diabetes mellitus.

Effective in the treatment of polycystic ovaries

This drug has shown efficacy in the treatment of patients with Polycystic Ovary Syndrome, because it improves their metabolic and glycemic profile and menstrual disorders . 

On the other hand, some studies have indicated that the administration of Metformin in these cases has contributed to reducing infertility and allowing pregnancy, by promoting a greater frequency of ovulation. 


Fights obesity and cardiovascular diseases

Obesity, excessive use of sugar in the diet , stress and lack of physical exercise cause cells to stop responding to insulin and absorb glucose. This insulin resistance increases the risk of cardiovascular disease.

So when insulin goes up, the body stops burning fat for fuel, and instead stores it, which is where Metformin counteracts this effect.

The side effects of metformin are:

Side effects that are not serious are similar to those of most medications.

•diarrhea and vomiting



•Abdominal pain

•loss of appetite


These symptoms may be normal when taking metformin.

Side effects of metformin that could be red flags are:


•Soft spot

•heavy breathing

•Difficulty breathing

•Alteration in heart rhythm

•skin redness


In addition; drinking alcohol during metformin treatment can cause lactic acidosis, which occurs when oxygen levels in the body drop.

These are the side effects of metformin, it is important to detect the effects that are considered a warning sign to prevent complications.

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